CREATE FUNCTIONAL ORGANOIDS WITH CELLOREON
Synthetic materials, Human tissues, Real impact
Synthetic materials, Human tissues, Real impact

CELLOREON is a spin-off from the DWI–Leibniz Institute for Interactive Materials developing microgel-based human organoid platforms for drug discovery, toxicity testing, and biomedical research. Using synthetic microgels, we generate a range of organoid and spheroid models, including cardiac, kidney, bone marrow, neural, and retinal organoids, designed to improve reproducibility, support animal-free workflows, and enable automation.
We are also developing 96-, 384-, and 1536-well plate-based organoid assays to support high-throughput and ultra-high-throughput screening applications. In addition, we provide customizable PEG-based microgels with tunable physical and biochemical properties that serve as versatile building blocks for 3D cell culture, tissue engineering, and organoid development.
Our technology addresses the limitations of animal-derived matrices such as Matrigel by offering a synthetic and scalable alternative designed to improve consistency and experimental control. By combining advanced biomaterials, automation, and data-driven analysis, CELLOREON delivers robust solutions for organoid research, personalized medicine, and translational applications.
Animal Free Materials
Klasen et al. report a new technology for human-induced pluripotent stem cell (iPSC)-based organoid production with iPSC expansion and differentiation in the same construct in a reproducible and scalable manner, compatible with high-throughput automation. This approach leverages the self-assembly of iPSCs with microgels to build three-dimensional constructs, driven by robust cell-material interactions achieved through vitronectin-coated polyethylene glycol (PEG)-based microgels. This technology allows the iPSCs to expand and retain their pluripotency, after which they can be differentiated into the three germ layers, providing a suitable platform for organoid differentiation.
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