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    • Home
    • Technology
      • Microgels
      • Organoid/Spheroid Models
    • Team
    • Contact
  • Home
  • Technology
    • Microgels
    • Organoid/Spheroid Models
  • Team
  • Contact

CREATE FUNCTIONAL ORGANOIDS WITH CELLOREON

CREATE FUNCTIONAL ORGANOIDS WITH CELLOREONCREATE FUNCTIONAL ORGANOIDS WITH CELLOREONCREATE FUNCTIONAL ORGANOIDS WITH CELLOREON

Synthetic materials, Human tissues, Real impact

Microgels
Organoid/Spheroid Models

CELLOREON is a spin-off from the DWI–Leibniz Institute for Interactive Materials developing microgel-based human organoid platforms for drug discovery, toxicity testing, and biomedical research. Using synthetic microgels, we generate a range of organoid and spheroid models, including cardiac, kidney, bone marrow, neural, and retinal organoids, designed to improve reproducibility, support animal-free workflows, and enable automation.


We are also developing 96-, 384-, and 1536-well plate-based organoid assays to support high-throughput and ultra-high-throughput screening applications. In addition, we provide customizable PEG-based microgels with tunable physical and biochemical properties that serve as versatile building blocks for 3D cell culture, tissue engineering, and organoid development.


Our technology addresses the limitations of animal-derived matrices such as Matrigel by offering a synthetic and scalable alternative designed to improve consistency and experimental control. By combining advanced biomaterials, automation, and data-driven analysis, CELLOREON delivers robust solutions for organoid research, personalized medicine, and translational applications.

A Future Where Discovery Doesn’t Hurt Animal

Animal Free Materials

Publications

Microgels enable iPSCs to assemble, expand, and differentiate into organoids

Klasen et al. report a new technology for human-induced pluripotent stem cell (iPSC)-based organoid production with iPSC expansion and differentiation in the same construct in a reproducible and scalable manner, compatible with high-throughput automation. This approach leverages the self-assembly of iPSCs with microgels to build three-dimensional constructs, driven by robust cell-material interactions achieved through vitronectin-coated polyethylene glycol (PEG)-based microgels. This technology allows the iPSCs to expand and retain their pluripotency, after which they can be differentiated into the three germ layers, providing a suitable platform for organoid differentiation.  

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CELLOREON

Forckenbeckstraße 50, Aachen, 52074

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